If you wanted to mostly follow a particular framework, there are two stats that each prefer. Not to say that you want to ignore the other stats, but these tend to hold more benefit.
When you pick a framework, you'll see on the bottom right, what it's energy builder, it's first main attack, and it's base stats will be.
If you want to still have the powers of a Power Armor type forexample, but want different stats, then go ahead and do custom framework, pick the energybuilder from Power Armor, and the first attack from it as well. Then you can pick a different set of starting stats.